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TLR9  Protein, Antibody, ELISA Kit, cDNA Clone

TLR9 相关研究领域

TLR9 相關信號通路

    TLR9 概述&蛋白信息

    TLR9 研究背景

    亞單位結構: Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. {ECO:0000250, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:20865800}.
    亞細胞定位: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.
    組織特異性: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
    相似的序列: Belongs to the Toll-like receptor family. {ECO:0000305}.; Contains 26 LRR (leucine-rich) repeats. {ECO:0000305}.; Contains 1 TIR domain. {ECO:0000255|PROSITE-ProRule:PRU00204}.
    General information above from UniProt

    TLR9 別稱

    TLR9 相關文獻

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