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TLR5/TIL3  Protein, Antibody, ELISA Kit, cDNA Clone

TLR5/TIL3 相关研究领域

TLR5/TIL3 相關信號通路

    TLR5/TIL3 概述&蛋白信息

    TLR5/TIL3 研究背景

    亞單位結構: Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of ligand. {ECO:0000250, ECO:0000269|PubMed:22173220}.
    亞細胞定位: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
    組織特異性: Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
    翻譯後修飾: Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines. {ECO:0000269|PubMed:17157808, ECO:0000269|PubMed:17442957}.; Phosphorylated at Tyr-798 upon flagellin binding; required for signaling. {ECO:0000269|PubMed:17157808, ECO:0000269|PubMed:17442957}.
    相關疾病 : DISEASE: Systemic lupus erythematosus 1 (SLEB1) [MIM:601744]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    相似的序列: Belongs to the Toll-like receptor family. {ECO:0000305}.; Contains 22 LRR (leucine-rich) repeats. {ECO:0000305}.; Contains 1 LRRCT domain. {ECO:0000305}.; Contains 1 TIR domain. {ECO:0000255|PROSITE-ProRule:PRU00204}.
    General information above from UniProt

    TLR5/TIL3 別稱

    TLR5/TIL3 相關文獻

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