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TLR3 / CD283  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
50161-M08H-50
50161-M08H-100
50 µg 
100 µg 
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  • Slide 1
表達宿主: Baculovirus-Insect Cells  
50161-M08B-50
50161-M08B-100
50 µg 
100 µg 
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TLR3 / CD283 相关研究领域

TLR3 / CD283 相關信號通路

    TLR3 / CD283 概述&蛋白信息

    TLR3 / CD283 研究背景

    基因概述: The protein encoded by this TLR3 gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. TLR3 may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this TLR3 gene.
    General information above from NCBI
    亞單位結構: Monomer and homodimer; dimerization is triggered by ligand-binding, the signaling unit is composed of one ds-RNA of around 40 bp and two TLR3 molecules, and lateral clustering of signaling units along the length of the ds-RNA ligand is required for TLR3 signal transduction. Interacts (via transmembrane domain) with UNC93B1; the interaction is required for transport from the ER to the endosomes. Interacts with TICAM1 (via the TIR domain); mediates TLR3 signaling. Interacts with SRC; upon binding of double-stranded RNA. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:22579623, ECO:0000269|PubMed:22611194}.
    結構域: ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18.
    亞細胞定位: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.
    組織特異性: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. {ECO:0000269|PubMed:17085778}.
    翻譯後修飾: Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding. {ECO:0000269|PubMed:15961631, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22579623}.; TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes. {ECO:0000269|PubMed:22611194}.
    相關疾病 : DISEASE: Herpes simplex encephalitis 2 (HSE2) [MIM:613002]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269|PubMed:17872438}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.
    相似的序列: Belongs to the Toll-like receptor family. {ECO:0000305}.; Contains 22 LRR (leucine-rich) repeats. {ECO:0000305}.; Contains 1 LRRCT domain. {ECO:0000305}.; Contains 1 LRRNT domain. {ECO:0000305}.; Contains 1 TIR domain. {ECO:0000255|PROSITE-ProRule:PRU00204}.
    General information above from UniProt

    Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    TLR3 / CD283 別稱

    CD283,TLR3, [human]
    AI957183,Tlr3, [mouse]

    TLR3 / CD283 相關文獻

  • Muzio M, et al.. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol. 164(11): 5998-6004.
  • Doyle S, et al.. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 17(3): 251-63.
  • Choe J, et al.. (2005) Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science. 309(5734): 581-5.
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