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TLR2 (CD282)  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Baculovirus-Insect Cells  
10061-H08B-50
10061-H08B-100
50 µg 
100 µg 
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  • Slide 1
表達宿主: Baculovirus-Insect Cells  
50502-M08B-50
50502-M08B-100
50 µg 
100 µg 
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  • Slide 1
表達宿主: Baculovirus-Insect Cells  
80400-R08B1-50
80400-R08B1-100
50 µg 
100 µg 
Add to Cart
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TLR2 (CD282) 相关研究领域

TLR2 (CD282) 相關信號通路

    TLR2 (CD282) 概述&蛋白信息

    TLR2 (CD282) 研究背景

    基因概述: The protein encoded by TLR2 gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    亞單位結構: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3 (By similarity). Interacts with ATG16L1. {ECO:0000250, ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:17889651, ECO:0000269|PubMed:23376921}.
    結構域: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12. {ECO:0000250}.; The ATG16L1-binding motif mediates interaction with ATG16L1. {ECO:0000269|PubMed:23376921}.
    亞細胞定位: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
    組織特異性: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
    翻譯後修飾: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. {ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651}.
    相似的序列: Belongs to the Toll-like receptor family. {ECO:0000305}.; Contains 19 LRR (leucine-rich) repeats. {ECO:0000305}.; Contains 1 LRRCT domain. {ECO:0000305}.; Contains 1 TIR domain. {ECO:0000255|PROSITE-ProRule:PRU00204}.
    General information above from UniProt

    TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathogen recognition and activation of innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 contains 14 LRR (leucine-rich) repeats and 1 TIR domain. TLR2 gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. CD282 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. CD282 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It may also promote apoptosis in response to lipoproteins.

    TLR2 (CD282) 別稱

    TLR2 (CD282) 相關文獻

  • Do KN, et al. (2012) TLR2 controls intestinal carcinogen detoxication by CYP1A1. PLoS ONE. 7 (3): e32309.
  • Dziarski R, et al. (2001) Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. J Endotoxin Res. 6 (5): 401-5.
  • Lorenz E, (2007) TLR2 and TLR4 expression during bacterial infections. Curr Pharm Des. 12 (32): 4185-93.
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