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TIM-3 / HAVCR2 抗體, 兔單抗

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     HAVCR2 抗體產品資訊
    免疫原:Recombinant Human TIM-3 / HAVCR2 protein (Catalog#10390-H08H)
    Clone ID:108
    Ig類型:Rabbit IgG
    濃度:
    內毒素:
    緩衝液:0.2 μm filtered solution in PBS
    抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human TIM-3 / HAVCR2 (rh TIM-3 / HAVCR2 ; Catalog#10390-H08H; NP_116171.3; Met1-Arg200).
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                TIM-3/HAVCR2  研究背景

                Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In tumor rejection model, soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.

                Immune Checkpoint
                Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: WB Antibodies
                Immune Checkpoint Proteins
                Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

                Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                 TIM-3/HAVCR2  參考資料
              • Geng H, et al. (2006) Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J Immunol. 176(3): 1411-20.
              • Anderson AC, et al. (2006) TIM-3 in autoimmunity. Curr Opin Immunol. 18(6): 665-9.
              • Anderson DE. (2007) TIM-3 as a therapeutic target in human inflammatory diseases. Expert Opin Ther Targets. 11(8): 1005-9.
              • Pan HF, et al. (2010) TIM-3 as a new therapeutic target in systemic lupus erythematosus. Mol Biol Rep. 37(1): 395-8.
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                Size / Price
                貨號: 10390-R108-100
                目錄價: 
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                Datasheet & Documentation

                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”