快速訂購

TIGIT/VSTM3  Protein, Antibody, ELISA Kit, cDNA Clone

描述:   
表達宿主: Human Cells  
  • Slide 1
10917-H08H-50
10917-H08H-20
10917-H08H-10
50 µg 
20 µg 
10 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
50939-M08H-50
50939-M08H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
50939-M02H-50
50939-M02H-100
50 µg 
100 µg 
Add to Cart

TIGIT/VSTM3 相关研究领域

TIGIT/VSTM3 相關信號通路

    TIGIT/VSTM3 概述&蛋白信息

    TIGIT/VSTM3 研究背景

    基因概述: TIGIT gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of TIGIT gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
    General information above from NCBI
    亞單位結構: Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to PVRL2 and PVRL3. {ECO:0000269|PubMed:22421438}.
    結構域: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    亞細胞定位: Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.
    組織特異性: Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). {ECO:0000269|PubMed:19011627}.
    相似的序列: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-10 and diminished the production of IL-12p40. In addition, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.

    Immune Checkpoint
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    TIGIT/VSTM3 別稱

    TIGIT/VSTM3 相關文獻

    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”