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TGF-beta 2  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
50153-M08H-50
50153-M08H-5
50153-M08H-100
50153-M08H-10
50 µg 
5 µg 
100 µg 
10 µg 
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表達宿主: Human Cells  
70099-D08H-20
70099-D08H-10
20 µg 
10 µg 
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表達宿主: Human Cells  
90036-K08H-50
90036-K08H-5
90036-K08H-10
50 µg 
5 µg 
10 µg 
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TGF-beta 2 相关研究领域

TGF-beta 2 相關信號通路

TGF-beta 2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

TGF-beta 2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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TGF-beta 2 概述&蛋白信息

TGF-beta 2 相關資訊

TGF-beta 2 研究背景

基因概述: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
General information above from NCBI
亞單位結構: Homodimer; disulfide-linked (By similarity). Heterodimers with TGFB1 and with TGFB3 have been found in bone (By similarity). Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity). Latency-associated peptide interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (By similarity). Interacts with ASPN. Interacts with MFAP5 (By similarity). {ECO:0000250|UniProtKB:Q9QZJ6, ECO:0000269|PubMed:17827158}.
亞細胞定位: Secreted.
翻譯後修飾: The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. {ECO:0000250}.
相關疾病 : DISEASE: Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.; DISEASE: Loeys-Dietz syndrome 4 (LDS4) [MIM:614816]: An aortic aneurysm syndrome with widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae. {ECO:0000269|PubMed:22772368}. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似的序列: Belongs to the TGF-beta family. {ECO:0000305}.
General information above from UniProt

TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. In addition, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD.

TGF-beta 2 別稱

TGF-beta 2 相關文獻

  • Schlingensiepen KH, et al. (2006) Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009. Cytokine Growth Factor Rev. 17(1-2): 129-39.
  • Ghatpande SK, et al. (2010) Transforming growth factor beta2 is negatively regulated by endogenous retinoic acid during early heart morphogenesis. Dev Growth Differ. 52(5): 433-55.
  • Noguchi A, et al. (2010) Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains. Int J Neurosci. 120(3): 168-75.
  • Li J, et al. (2011) Comparative effects of TGF-_2/Smad2 and TGF-_2/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line. Exp Eye Res. 92(3): 173-9.
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