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TACI/TNFRSF13B(CD267)  Protein, Antibody, ELISA Kit, cDNA Clone

TACI/TNFRSF13B(CD267) 相关研究领域

TACI/TNFRSF13B(CD267) 相關信號通路

TACI/TNFRSF13B(CD267) 相關蛋白、抗體、cDNA基因、ELISA試劑盒

TACI/TNFRSF13B(CD267) 概述&蛋白信息

TACI/TNFRSF13B(CD267) 研究背景

基因概述: The protein encoded by this TNFRSF13B gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. TNFRSF13B interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This TNFRSF13B gene is located within the Smith-Magenis syndrome region on chromosome 17.
General information above from NCBI
亞單位結構: Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus. {ECO:0000269|PubMed:15542592}.
亞細胞定位: Membrane; Single-pass type III membrane protein.
組織特異性: Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.
相關疾病 : DISEASE: Immunodeficiency, common variable, 2 (CVID2) [MIM:240500]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:16007086}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Immunoglobulin A deficiency 2 (IGAD2) [MIM:609529]: Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology. {ECO:0000269|PubMed:16007086}. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似的序列: Contains 2 TNFR-Cys repeats. {ECO:0000305}.
General information above from UniProt

Tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) also known as Transmembrane activator and CAML interactor (TACI) and CD267 antigen, is a member of the tumor necrosis factor receptor superfamily. TNFRSF13B is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. TACI/TNFRSF13B/CD267 induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand.

TACI/TNFRSF13B(CD267) 別稱

CVID,RYZN,TACI,CD267,CVID2,IGAD2,TNFRSF14B, [homo-sapiens]
CD267,CVID,CVID2,FLJ39942,MGC133214,MGC39952,TACI,TNFRSF13B,TNFRSF14B, [human]
1200009E08Rik,RP23-55I2.2,Taci,Tnfrsf13b, [mouse]
Taci,1200009E08Rik, [mus-musculus]

TACI/TNFRSF13B(CD267) 相關文獻

  • Salzer U, et al. (2005) Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet. 37(8): 820-8.
  • Salzer U, et al. (2009) Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes. Blood. 113(9): 1967-76.
  • Mohammadi J, et al. (2009) Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency. J Clin Immunol. 29(6): 777-85.
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