快速訂購

首頁>產品>Virus>Coronavirus>Coronavirus spike
Text Size:AAA

Coronavirus  spike

Coronavirus  spike  蛋白和抗體

Spike 蛋白Spike 抗體Spike 基因Spike 
Product NameMoleculeCat No.Package/Price 
人冠狀病毒 spike glycoprotein 蛋白 (isolate HKU1) (aa 1-760, His 標籤)spike 40021-V08H-5
40021-V08H-100
40021-V08H-20
40021-V08H-50
5 µg/
100 µg/
20 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
MERS-CoV (NCoV / Novel coronavirus) Spike 蛋白 (ECD, aa 1-1297, His 標籤)spike 40069-V08B-5
40069-V08B-100
40069-V08B-20
40069-V08B-50
5 µg/
100 µg/
20 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
MERS-CoV (NCoV / Novel coronavirus) Spike 蛋白 S1 蛋白 (aa 1-725, His 標籤)spike 40069-V08B1-5
40069-V08B1-100
40069-V08B1-20
40069-V08B1-50
5 µg/
100 µg/
20 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
MERS-CoV (NCoV / Novel coronavirus) Spike 蛋白 S1 (aa 1-725, His 標籤)spike 40069-V08H-5
40069-V08H-100
40069-V08H-20
40069-V08H-50
5 µg/
100 µg/
20 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
MERS-CoV (NCoV / Novel coronavirus) Spike 蛋白 S2 (aa 726-1296, His 標籤)spike 40070-V08B-5
40070-V08B-100
40070-V08B-20
40070-V08B-50
5 µg/
100 µg/
20 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
MERS-CoV (NCoV / Novel coronavirus) Spike 蛋白 fragment (aa 383-502, Fc 標籤)spike 40071-V05B-5
40071-V05B-100
40071-V05B-20
40071-V05B-50
5 µg/
100 µg/
20 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
MERS-CoV (NCoV / Novel coronavirus) Spike 蛋白 fragment (RBD, aa 367-606, His 標籤)spike 40071-V08B1-20
40071-V08B1-5
40071-V08B1-100
40071-V08B1-50
20 µg/
5 µg/
100 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
MERS-CoV (NCoV / Novel coronavirus) Spike 蛋白 fragment (aa 383-502, Fc 標籤)spike 40071-V31B-5
40071-V31B-100
40071-V31B-20
40071-V31B-50
5 µg/
100 µg/
20 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
MERS-CoV (NCoV / Novel coronavirus) Spike 蛋白 fragment (aa 367-606, Fc 標籤)spike 40071-V31B1-5
40071-V31B1-20
40071-V31B1-100
40071-V31B1-50
5 µg/
20 µg/
100 µg/
50 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
SARS冠狀病毒 Spike S1 Subunit 蛋白 (His 標籤)spike 40150-V08B1-5
40150-V08B1-50
40150-V08B1-20
40150-V08B1-100
5 µg/
50 µg/
20 µg/
100 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
SARS冠狀病毒 Spike 蛋白 (Receptor Binding Domain, His 標籤)spike 40150-V08B2-5
40150-V08B2-50
40150-V08B2-20
40150-V08B2-100
5 µg/
50 µg/
20 µg/
100 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart
SARS冠狀病毒 Spike 蛋白 (Receptor Binding Domain, Fc 標籤)spike 40150-V31B2-5
40150-V31B2-50
40150-V31B2-20
40150-V31B2-100
5 µg/
50 µg/
20 µg/
100 µg/
Add to Cart
Add to Cart
Add to Cart
Add to Cart

Coronavirus spike  背景

The Human Coronavirus (HCoV) Spike Glycoprotein is one of the four major structural proteins of the coronavirus. Coronavirus entry is mediated by the viral Human Coronavirus (HCoV) Spike Glycoprotein. The 180-kDa oligomeric Human Coronavirus (HCoV) Spike Glycoprotein of the murine coronavirus mouse hepatitis virus strain A59 is posttranslationally cleaved into an S1 receptor binding unit and an S2 membrane fusion unit. The latter is thought to contain an internal fusion peptide and has two 4,3 hydrophobic (heptad) repeat regions designated HR1 and HR2. HR2 is located close to the membrane anchor, and HR1 is some 170 amino acids (aa) upstream of it. Heptad repeat (HR) regions are found in fusion proteins of many different viruses and form an important characteristic of class I viral fusion proteins. We investigated the role of these regions in coronavirus membrane fusion. Peptides HR1 (96 aa) and HR2 (39 aa), corresponding to the HR1 and HR2 regions, were produced in Escherichia coli. When mixed together, the two peptides were found to assemble into an extremely stable oligomeric complex. Both on their own and within the complex, the peptides were highly alpha helical. Electron microscopic analysis of the complex revealed a rod-like structure. Limited proteolysis in combination with mass spectrometry indicated that HR1 and HR2 occur in the complex in an antiparallel fashion. In the native protein, such a conformation would bring the proposed fusion peptide, located in the N-terminal domain of HR1, and the transmembrane anchor into close proximity. Using biological assays, the HR2 peptide was shown to be a potent inhibitor of virus entry into the cell, as well as of cell-cell fusion. Both biochemical and functional data show that the coronavirus Human Coronavirus (HCoV) Spike Glycoprotein is a class I viral fusion protein.

HCoV-EMC is a novel coronavirus isolated from a Saudi patient presenting with pneumonia and renal failure in June 2012. Coronaviruses primarily cause respiratory and enteric diseases in mammals and birds. Coronavirus symptoms include rhinorrhea, sneezing, cough, nasal obstruction, bronchitis and so on. In 2003, a novel coronavirus which is known as SARS coronavirus cause the severe acute respiratory syndrome (SARS) epidemic that began in Asia in 2002. Genome sequencing showed that this virus belongs to the group C species of the genus betacoronavirus and phylogenetically related to the bat coronaviruses HKU4 and HKU5 previously found in lesser bamboo bat and Japanese Pipistrelle bat of Hong Kong respectively. HCoV-EMC has been identified as a highly lethal virus that could be passed from animals to humans very easily. The virus, like other coronaviridae, has the potential to infect bats and pigs in addition to humans. HCoV-EMC is related to the causative agent of SARS (severe acute respiratory syndrome), SARS coronavirus, and also may be even more infectious as it does not use the human receptor protein ACE2. The receptor used by HCov-EMC has not been identified. Symptoms of infection include kidney failure and severe pneumonia. The animal source has still not been identified but may circulate among populations of bats.

Coronavirus spike  參考文獻

  1. Sander van Boheemen, et al. (2012) Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans. mBio 3(6): e00473-12.
  2. Muller, M. A, et al. (2012) Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capability in Mammalian Cell Lines. mBio 3(6): e00515-12 -12.
  3. Chan JF, et al. (2012) Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?. J Infect. 65(6):477-89.
請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”