Anti-SOX2 Antibody

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Anti-SOX2 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-SOX2 Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human SOX2
Immunogen
A synthetic peptide corresponding to the N-terminus of the human Sox2.
Preparation
This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the N-terminus of the human Sox2.
Source
Monoclonal Rabbit IgG Clone #017
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SOX2 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SOX2 Antibody (Rabbit Monoclonal antibody) Images

Immunochemical staining of human SOX2 in human testis with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections).
Immunochemical staining of human SOX2 in human brain with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections).

Anti-SOX2 Antibody: Alternative Names

Anti-ANOP3 Antibody; Anti-MCOPS3 Antibody

SOX2 Background Information

SOX2, also known as ANOP3, is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP26. SOX2 is critical for early embryogenesis and for embryonic stem cell pluripotency. It keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Defects in SOX2 can cause microphthalmia, syndromic, 3. A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
Full Name
SRY (sex determining region Y)-box 2
References
  • Lu Y, et al., 2010, PLoS ONE. 5(6): e11022.
  • Gontan C, et al., 2008, Dev. Biol. 317 (1): 296-309.
  • Shi W, et al., 2006, J. Biol. Chem. 281 (33): 23319-25.
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