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SerpinD1 抗體, 兔單抗

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Human SERPIND1 抗體產品資訊
免疫原:Recombinant Human SerpinD1 protein (Catalog#10295-H08H)
Clone ID:008
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS with 5% trehalose
抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinD1 (rh SerpinD1; Catalog#10295-H08H; NP_000176.2; Met1-Ser499).
Human SERPIND1 抗體使用指導
特異性:Human SerpinD1
Has cross-reactivity in ELISA with
Mouse SerpinD1
No cross-reactivity in ELISA with
Human SerpinA3
Human SerpinC1
Human SerpinI1
Mouse SerpinF1
推薦應用:IHC-P

IHC-P: 1-10 μg/mL

儲存方法:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human SERPIND1 Antibody IHC Application Image
SerpinD1 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human serpinD1 in human hepatoma with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.
SerpinD1 Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human serpinD1 in human liver with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.
Other SERPIND1 Antibody Products
SerpinD1 研究背景

SerpinD1, also known as heparin cofactor II (HCâ…¡), is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.

Human SerpinD1 參考資料
  • Rau JC, et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol. 87(3): 178-83.
  • Aihara K, et al. (2009) Heparin cofactor II as a novel vascular protective factor against atherosclerosis. J Atheroscler Thromb. 16(5): 523-31.
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    貨號: 10295-R008-50
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    產品圖片
    • SerpinD1 Antibody, Rabbit MAb, Immunohistochemistry
    • SerpinD1 Antibody, Rabbit MAb, Immunohistochemistry
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