Anti-SerpinD1 Antibody

Cat: 10295-R008
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Anti-SerpinD1 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-SerpinD1 Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human SerpinD1
Has cross-reactivity in ELISA with Mouse SerpinD1
No cross-reactivity in ELISA with Human SerpinA3 Human SerpinC1 Human SerpinI1 Mouse SerpinF1
Immunogen
Recombinant Human SerpinD1 protein (Catalog#10295-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinD1 (rh SerpinD1; Catalog#10295-H08H; NP_000176.2; Met1-Ser499).
Source
Monoclonal Rabbit IgG Clone #008
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SerpinD1 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SerpinD1 Antibody (Rabbit Monoclonal antibody) Images
Human SerpinD1 Immunohistochemistry(IHC) 3616
Immunochemical staining of human serpinD1 in human liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.
Human SerpinD1 Immunohistochemistry(IHC) 3618
Immunochemical staining of human serpinD1 in human hepatoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.
Anti-SerpinD1 Antibody Alternative Names
Anti-D22S673 Antibody;Anti-HC2 Antibody;Anti-HCF2 Antibody;Anti-HCII Antibody;Anti-HLS2 Antibody;Anti-LS2 Antibody;Anti-SerpinD1 Antibody;Anti-THPH10 Antibody
SerpinD1 Background Information

SerpinD1, also known as heparin cofactor II (HCâ…¡), is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.

Full Name
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
References
  • Rau JC, et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol. 87(3): 178-83.
  • Aihara K, et al. (2009) Heparin cofactor II as a novel vascular protective factor against atherosclerosis. J Atheroscler Thromb. 16(5): 523-31.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SerpinD1 Antibody Rabbit Polyclonal ELISA 50121-RP01
    Anti-SerpinD1 Antibody Rabbit Monoclonal WB,ELISA,IP 50121-R025
    Anti-SerpinD1 Antibody Rabbit Polyclonal ELISA,IHC-P 50121-RP02
    Anti-SerpinD1 Antibody Rabbit Polyclonal WB,ELISA 10295-RP01
    Anti-SerpinD1 Antibody Rabbit Polyclonal WB,ELISA,IP 10295-RP02
    Anti-SerpinD1 Antibody Mouse Monoclonal ELISA 10295-MM02
    Anti-SerpinD1 Antibody Mouse Monoclonal IHC-P 10295-MM07
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