快速訂購

留言    收藏

SMAD3 抗體, 兔多抗, 抗原親和純化

  • SMAD3 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
  • SMAD3 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
產品資料評論相關產品實驗方法
 SMAD3 抗體產品資訊
免疫原:A synthetic peptide corresponding to the center region of the human SMAD3
Clone ID:
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS
抗體製備方法:Produced in rabbits immunized with A synthetic peptide corresponding to the center region of the human SMAD3, and purified by antigen affinity chromatography.
 SMAD3 Antibody WB Application Image
 SMAD3 Antibody IP Application Image
Other SMAD3 Antibody Products
Smad3 研究背景

SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice, mutation of SMAD3 has been linked to colorectal adenocarcinoma, increased systemic inflammation, and accelerated wound healing. Increased SMAD3 activity has been implicated in the pathogenesis of scleroderma. Smad3 is also a multifaceted regulator in adipose physiology and the pathogenesis of obesity and type 2 diabetes.

 Smad3 參考資料
  • Tan. et al., 2011, Diabetes. 60 (2): 464-76.
  • Yang X. et al., 1999, Nat Cell Biol. 1 (5): 260-6.
  • Zhu Y. et al., 1998, Cell. 94 (6): 703-14.
  • Feng X. et al., 1996, Nature. 383 (6596): 168-72.
  • Product nameProduct name
    Size / Price
    貨號: 100424-T36-100
    目錄價: 
    單價:      (You Save: )

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”