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SCGN / Secretagogin 抗體, 鼠單抗

產品資料評論相關產品實驗方法
Human SCGN 抗體產品資訊
免疫原:Recombinant Human SCGN / Secretagogin protein (Catalog#12411-H07E)
Clone ID:06
Ig類型:Mouse IgG1
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS with 5% trehalose
抗體製備方法:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SCGN / Secretagogin (rh SCGN / Secretagogin; Catalog#12411-H07E; NP_008929.2; Asp2-Pro276). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human SCGN 抗體使用指導
特異性:Human SCGN / Secretagogin
推薦應用:IHC-P

IHC-P: 10-30 μg/mL

儲存方法:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human SCGN Antibody IHC Application Image
SCGN / Secretagogin Antibody, Mouse MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human SCGN in human pancreas with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections).
Other SCGN Antibody Products
SCGN / Secretagogin 研究背景

Secretagogin, also known as SCGN, is a secreted protein which is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. Secretagogin / SCGN is widely expressed in prostatic adenocarcinoma as opposed to adenocarcinomas in other organs. The function of Secretagogin / SCGN is unknown, but it has been suggested in beta-cells to influence calcium-influx and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. Secretagogin / SCGN is involved in the calcium metabolism of tumour cells and endothelial cells in a subset of neoplasms of the brain and its coverings. Secretagogin / SCGN is also a novel marker for neuroendocrine differentiation.

Human SCGN / Secretagogin 參考資料
  • Birkenkamp-D,K. et al., 2005, Neuroendocrinology. 82 (2):121-38.
  • Skovhus,K.V. et al., 2006, Scand J Immunol. 64 (6):639-45.
  • Pipp,I. et al., 2007, APMIS.115 (4):319-26.
  • Rogstam, A. et al., 2007, Biochem J. 401 (1):353-63.
  • Adolf,K. et al., 2007, Prostate. 67 (5):472-84.
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    貨號: 12411-MM06-50
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    • SCGN / Secretagogin Antibody, Mouse MAb, Immunohistochemistry
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