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SR-BI/SCARB1/CD36L1  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
11069-H03H-20
11069-H03H-100
11069-H03H-10
20 µg 
100 µg 
10 µg 
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表達宿主: Human Cells  
11069-H08H-20
11069-H08H-10
20 µg 
10 µg 
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表達宿主: Human Cells  
50317-M03H-50
50317-M03H-20
50 µg 
20 µg 
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  • Slide 1
表達宿主: Human Cells  
50317-M08H-50
50317-M08H-20
50 µg 
20 µg 
Add to Cart
  • Slide 1

SR-BI/SCARB1/CD36L1 相关研究领域

SR-BI/SCARB1/CD36L1 相關信號通路

    SR-BI/SCARB1/CD36L1 概述&蛋白信息

    SR-BI/SCARB1/CD36L1 研究背景

    基因概述: The protein encoded by SCARB1 gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for SCARB1 gene.[provided by RefSeq, Mar 2011]
    General information above from NCBI
    亞單位結構: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. The C-terminal region binds to PDZK1 (By similarity). {ECO:0000250}.
    亞細胞定位: Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
    組織特異性: Widely expressed.
    翻譯後修飾: N-glycosylated. {ECO:0000269|PubMed:12016218, ECO:0000269|PubMed:19159218}.; The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. {ECO:0000250}.
    相似的序列: Belongs to the CD36 family. {ECO:0000305}.
    General information above from UniProt

    Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogical processes. As a key component in the reverse cholesterol transport pathway, SCARB1 binds high density lipoproteins (HDLs) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SCARB1 may thus serve as a useful marker that predicts variation in baseline lipid levels and postprandial lipid response. The mouse SCARB1 has been shown to exert actions in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.

    SR-BI/SCARB1/CD36L1 別稱

    CLA1,SRB1,CLA-1,SR-BI,CD36L1,HDLQTL6, [homo-sapiens]
    CD36L1,CLA1,CLA-1,MGC138242,SCARB1,SRB1,SR-BI, [human]
    AI120173,CD36,Cd36l1,Cla1,Cla-1,D5Ertd460e,mSR-BI,Scarb1,Srb1,SR-B1,SRBI,SR-BI, [mouse]
    CD36,Cla1,SRBI,Srb1,Cla-1,Hdlq1,SR-B1,SR-BI,Cd36l1,Hlb398,mSR-BI,AI120173,D5Ertd460e, [mus-musculus]

    SR-BI/SCARB1/CD36L1 相關文獻

  • Murao, K. et al., 1997, J. Biol. Chem. 272(28): 17551-17557.
  • Ikemoto, M. et al., 2000, Proc. Natl. Acad. Sci. U.S.A. 97 (12): 6538-6543.
  • Husemann, J. et al., 2001, Am. J. Pathol. 158 (3): 825-832. 
  • Williams, D.L. et al., 2001, Endocr. Res. 26 (4): 639-651.
  • Bulte, B. S. et al., 2002, J. Biol. Chem. 277 (39): 36092-36099.
  • Duncan, K.G. et al., 2002, Biochem. Biophys. Res. Commun. 292 (4): 1017-1022. 
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