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SAMHD1  Protein, Antibody, ELISA Kit, cDNA Clone

SAMHD1 相关研究领域

SAMHD1 相關信號通路

    SAMHD1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    SAMHD1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    SAMHD1 概述&蛋白信息

    SAMHD1 研究背景

    催化活性: dNTP + H(2)O = Deoxynucleoside + triphosphate. {ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:24217394}.
    輔因數: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:24141705}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:24141705};
    酶調控: ENZYME REGULATION: Allosterically stimulated by dGTP which binds in a cleft at the interface of the homodimer and promotes the formation of highly active homotetramers. Each allosteric site binds two molecules of dGTP (dGTP1 and dGTP 2) between adjoining subunits. Not activated by dATP, dCTP and dTTP. {ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394}.
    亞單位結構: Homodimer. Homotetramer; in dGTP-bound form. After HIV infection, interacts (via C-terminus) with a ubiquitin-protein ligase complex containing VPRBP and the viral accessory protein Vpx. {ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198}.
    亞細胞定位: Nucleus {ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:23092512}.
    組織特異性: Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus. {ECO:0000269|PubMed:11064105}.
    誘導: By IFNG/IFN-gamma. Up-regulated in TNF treated lung fibroblasts. {ECO:0000269|PubMed:11064105, ECO:0000269|PubMed:18546154}.
    翻譯後修飾: Ubiquitinated and targeted for proteasomal degradation by a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase with the help of the viral accessory protein Vpx. {ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:24336198}.
    相關疾病 : DISEASE: Aicardi-Goutieres syndrome 5 (AGS5) [MIM:612952]: A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. {ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:20131292, ECO:0000269|PubMed:20842748}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Chilblain lupus 2 (CHBL2) [MIM:614415]: A rare cutaneous form of lupus erythematosus. Affected individuals present with painful bluish-red papular or nodular lesions of the skin in acral locations precipitated by cold and wet exposure at temperatures less than 10 degrees centigrade. {ECO:0000269|PubMed:21204240}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the SAMHD1 family. {ECO:0000305}.; Contains 1 HD domain. {ECO:0000305}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
    General information above from UniProt

    SAMHD1 別稱

    DCIP,CHBL2,HDDC1,MOP-5,SBBI88, [homo-sapiens]
    Mg11,E330031J07Rik, [mus-musculus]

    SAMHD1 相關文獻