S100A2 Protein, Human, Recombinant (Fc Tag)

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S100A2 Protein, Human, Recombinant (Fc Tag): Product Information

Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human S100A2 (NP_005969.1) (Met 2-Pro98) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Accession#
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Glu 20
Molecule Mass
The recombinant human Fc/S100A2 is a disulfide-linked homodimer. The reduced monomer consists of 334 amino acids and has a predicted molecular mass of 37.6 kDa. As a result of glycosylation, the apparent molecular mass of rh Fc/S100A2 monomer is approximately 40 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

S100A2 Protein, Human, Recombinant (Fc Tag): Images

S100A2 Protein, Human, Recombinant (Fc Tag): Alternative Names

CAN19 Protein, Human; S100L Protein, Human

S100A2 Background Information

The calcium-binding Protein S1A2 is a member of the S1 family of proteins containing 2 EF-hand calcium-binding motifs. S1 family genes are located as a cluster on chromosome 1q21, and S1 proteins consisting of at least 2 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S1A2 was first detected in lung and kidney, and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S1A2 protein is a homodimer that undergoes a conformational change upon binding of calcium, and the active form functions in regulating cell proliferation and differentiation, gene transcription, and p53-dependent growth arrest and apoptosis. Accordingly, this protein is regarded as a putative tumor suppressor, and thus chromosomal rearrangements and reduced expression of S1A2 gene have been implicated in certain carcinomas.
Full Name
S100 calcium binding protein A2
References
  • Gimona, M. et al., 1997, J. Cell. Sci. 110: 611-621.
  • Mueller, A. et al., 2005, J. Biol. Chem. 280: 29186-29193.
  • Lapi, E. et al., 2006, Oncogene. 25: 3628-3637.
  • Feng, G. et al., 2001, Cancer. Res. 61: 7999-8004.
  • Gupta, S. et al., 2003, J. Clin. Oncol. 21: 106-112.
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