Anti-S100A12 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Not React with: Mouse, Rat
Recombinant Human S100A12 protein (Catalog#11143-HNAE)
Produced in rabbits immunized with purified, recombinant Human S100A12 (rh S100A12; Catalog#11143-HNAE; NP_005612.1; Met 1-Glu 92). S100A12 specific IgG was purified by human S100A12 affinity chromatography
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-S100A12 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-S100A12 Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of human S100A12 in human spleen with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections).
Anti-S100A12 Antibody Alternative Names
Anti-CAAF1 Antibody;Anti-CAGC Antibody;Anti-CGRP Antibody;Anti-ENRAGE Antibody;Anti-MRP-6 Antibody;Anti-MRP6 Antibody;Anti-p6 Antibody;Anti-S100A12 Antibody
S100A12 Background Information
S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.
Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. S100A12 plays an important role in the inflammatory response.
S100 calcium binding protein A12
Moroz, OV. et al., 2001, Acta Crystallogr D Biol Crystallogr. 57: 20-9. Foell, D. et al., 2003, Lancet 361 (9365):1270-2. Vogl, T. et al., 2004, Blood. 104: 4260-8. Viemann, D. et al., 2005, Blood. 105: 2955-62. Nakatani, Y. et al., 2005, Mediators Inflamm. 2005: 280-292. Bjoerk, P. et al., 2009, PLoS Biol. 7: E97-E97.