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大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-His 標籤

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Rat PTPRC cDNA Clone產品資訊
註冊碼:NM_001109890.1
cDNA基因長度:3426bp
cDNA基因描述:Full length Clone DNA of Rattus norvegicus protein tyrosine phosphatase, receptor type, C, transcript variant 1 with C terminal His tag.
基因別名:Lca, RT7, CD45, L-CA, T200, Ptprc
分子種屬:Rat
載體:pCMV3-C-His
Plasmid:
限制性酶切位點:
Tag序列:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
序列資訊:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
運輸條件:Each tube contains lyophilized plasmid.
儲存方法:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.

大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-His 標籤 on other vectors
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤RG80296-ACGNT$11770
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤RG80296-ACRNT$11770
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-GFPSpark 標籤RG80296-ANGNT$11770
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-OFPSpark 標籤RG80296-ANRNT$11770
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤RG80296-CFNT$10690
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-His 標籤RG80296-CHNT$10690
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤RG80296-CMNT$10690
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤RG80296-CYNT$10690
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF(克隆載體)RG80296-GNT$2720
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤RG80296-NFNT$10690
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤RG80296-NHNT$10690
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤RG80296-NMNT$10690
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤RG80296-NYNT$10690
大鼠 CD45/PTPRC transcript variant 1 基因全長cDNA ORF克隆 (表達載體)RG80296-UTNT$10690
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研究背景

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexs or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.

參考資料
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Irie-Sasaki J, et al. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling. Nature. 409: 349-54.
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