|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤||RG80315-ACG|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤||RG80315-ACR|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤||RG80315-CF|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), C-His 標籤||RG80315-CH|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤||RG80315-CM|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤||RG80315-CY|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF(克隆載體)||RG80315-G|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤||RG80315-NF|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤||RG80315-NH|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤||RG80315-NM|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤||RG80315-NY|
|大鼠 Contactin 1/CNTN1 基因全長cDNA ORF克隆 (表達載體)||RG80315-UT|
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-1 is a cell surface adhesion molecule that is normally expressed by neurons and oligodendrocytes. Particularly high levels of Contactin-1 are present during brain development. Contactin-1 and Contactin-2 are differentially expressed in a number of neuronal tissues during development, and they interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. As a cell adhesion molecule, Contactin-1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that Contactin-1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1. Contactin-1 is also involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that Contactin-1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells. Contactin-1 may also significantly influence the functional expression and distribution of Na+ channels in neurons.