All RSPO1 reagents are produced in house and quality controlled, including 4 RSPO1 Antibody, 26 RSPO1 Gene, 4 RSPO1 Lysate, 4 RSPO1 Protein, 2 RSPO1 qPCR. All RSPO1 reagents are ready to use.
Recombinant RSPO1 proteins are expressed by CHO Stable Cells, HEK293 Cells with fusion tags as Native, C-His.
RSPO1antibodies are validated with different applications, which are WB, ELISA, IHC-P.
RSPO1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each RSPO1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.