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ROR1/NTRKR1  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
    13968-H08H-100
    13968-H08H-20
    100 µg 
    20 µg 
    Add to Cart
    表達宿主: Baculovirus-Insect Cells  
    • Slide 1
    13968-H20B-20
    13968-H20B-50
    20 µg 
    50 µg 
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    表達宿主: Human Cells  
    • Slide 1
    13968-H02H1-50
    13968-H02H1-100
    50 µg 
    100 µg 
    Add to Cart

    ROR1/NTRKR1 相關信號通路

      ROR1/NTRKR1 概述&蛋白信息

      ROR1/NTRKR1 研究背景

      基因概述: ROR1 gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. ROR1 gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of ROR1 gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
      General information above from NCBI
      催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
      亞細胞定位: Membrane; Single-pass type I membrane protein.
      組織特異性: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
      發育階段: Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
      相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
      Contains 1 FZ (frizzled) domain.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 kringle domain.
      Contains 1 protein kinase domain.C
      General information above from UniProt

      ROR1/NTRKR1 別稱

      NTRKR1,dJ537F10.1, [homo-sapiens]
      dJ537F10.1,neurotrophic tyrosine kinase,NTRKR1,receptor tyrosine kinase-like orphan receptor 1,receptor-related 1,ROR1,RP11-24J23.1,tyrosine-protein kinase transmembrane receptor ROR1, [human]
      2810404D04Rik,mRor1,neurotrophic tyrosine kinase,Ntrkr1,receptor related 1,receptor tyrosine kinase-like orphan receptor 1,Ror1,RP23-408D7.2,tyrosine-protein kinase transmembrane receptor ROR1, [mouse]
      mRor1,Ntrkr1,2810404D04Rik, [mus-musculus]

      ROR1/NTRKR1 相關文獻

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