Anti-PTH / Parathyroid Hormone Antibody

Cat: 13192-T08
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Anti-PTH / Parathyroid Hormone Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PTH / Parathyroid Hormone Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human PTH / Parathyroid Hormone
Immunogen
Recombinant Human PTH / PTH1 / Parathyroid Hormone protein (Catalog#13192-H09E)
Preparation
Produced in rabbits immunized with purified, recombinant Human PTH / PTH1 / Parathyroid Hormone (rh PTH / PTH1 / Parathyroid Hormone; Catalog#13192-H09E; P05062; Ser32-Phe65). PTH / PTH1 / Parathyroid Hormone specific IgG was purified by Human PTH / PTH1 / Parathyroid Hormone affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PTH / Parathyroid Hormone Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
IHC-P 1:1000-1:4000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PTH / Parathyroid Hormone Antibody (Rabbit Polyclonal antibody) Images
Human PTH / PTH1 / Parathyroid Hormone Immunohistochemistry(IHC) 17432
Immunochemical staining of human PTH in human kindey with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Human PTH / PTH1 / Parathyroid Hormone Immunohistochemistry(IHC) 17431
Immunochemical staining of human PTH in human liver with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Anti-PTH / Parathyroid Hormone Antibody Alternative Names
Anti-PTH Antibody;Anti-PTH1 Antibody
PTH / Parathyroid Hormone Background Information

Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Parathyroid hormone (PTH) has been proved to play a pivotal role in maintaining myocardial contractility as well as effective natriuresis, and possible pathogenic mechanisms contributing to heart failure secondary to hypocalcemia and hypoparathyroidism. With the increased population of preosteoblastic lineages and the osteoblastic activation, Parathyroid hormone (PTH) drives anabolism in bone. Experiments have recently reported that PTH affects bone cells in a dual pathway - mediating osteoblastic (preosteoblastic) activities or osteocytic synthesis of sclerostin. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.

Full Name
parathyroid hormone
References
  • Bedi B, et al. (2012) Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci U S A. 109(12): 725-33.
  • Hasegawa T, et al. (2012) Parathyroid hormone as a Bone anabolic agent. Biological function of bone cells on the PTH-driven anabolic effect. Clin Calcium. 22(3): 373-9.
  • Ito M. Parathyroid hormone as a Bone anabolic agent. Effect of PTH on bone structural properties. Clin Calcium. 22(3): 335-41.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PTH / Parathyroid Hormone Antibody Mouse Monoclonal ELISA 13192-MM03
    Anti-PTH / Parathyroid Hormone Antibody Mouse Monoclonal ELISA(Cap) 13192-MM02
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