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PTH / PTH1 / Parathyroid Hormone 抗體, 兔多抗, 抗原親和純化

  • Human PTH / PTH1 / Parathyroid Hormone Immunohistochemistry(IHC) 17431
  • Human PTH / PTH1 / Parathyroid Hormone Immunohistochemistry(IHC) 17432
產品資料評論相關產品實驗方法
 PTH 抗體產品資訊
免疫原:Recombinant Human PTH / PTH1 / Parathyroid Hormone protein (Catalog#13192-H09E)
Clone ID:
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS
抗體製備方法:Produced in rabbits immunized with purified, recombinant Human PTH / PTH1 / Parathyroid Hormone (rh PTH / PTH1 / Parathyroid Hormone; Catalog#13192-H09E; P05062; Ser32-Phe65). PTH / PTH1 / Parathyroid Hormone specific IgG was purified by Human PTH / PTH1 / Parathyroid Hormone affinity chromatography.
Other PTH Antibody Products
Immunochemical staining of human PTH in human kindey with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
PTH / PTH1 / Parathyroid Hormone 研究背景

Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Parathyroid hormone (PTH) has been proved to play a pivotal role in maintaining myocardial contractility as well as effective natriuresis, and possible pathogenic mechanisms contributing to heart failure secondary to hypocalcemia and hypoparathyroidism. With the increased population of preosteoblastic lineages and the osteoblastic activation, Parathyroid hormone (PTH) drives anabolism in bone. Experiments have recently reported that PTH affects bone cells in a dual pathway - mediating osteoblastic (preosteoblastic) activities or osteocytic synthesis of sclerostin. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.

 PTH / PTH1 / Parathyroid Hormone 參考資料
  • Bedi B, et al. (2012) Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci U S A. 109(12): 725-33.
  • Hasegawa T, et al. (2012) Parathyroid hormone as a Bone anabolic agent. Biological function of bone cells on the PTH-driven anabolic effect. Clin Calcium. 22(3): 373-9.
  • Ito M. Parathyroid hormone as a Bone anabolic agent. Effect of PTH on bone structural properties. Clin Calcium. 22(3): 335-41.
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    貨號: 13192-T08-200
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