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PKC epsilon/PRKCE  Protein, Antibody, ELISA Kit, cDNA Clone

PKC epsilon/PRKCE 相关研究领域

PKC epsilon/PRKCE 相關蛋白、抗體、cDNA基因、ELISA試劑盒

PKC epsilon/PRKCE 概述&蛋白信息

PKC epsilon/PRKCE 研究背景

催化活性: ATP + a protein = ADP + a phosphoprotein.
酶調控: ENZYME REGULATION: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.
亞單位結構: Forms a ternary complex with TRIM63 and GN2BL1. Can form a complex with PDLIM5 and N-type calcium channel. Interacts with COPB1 and YWHAB (By similarity). Interacts with DGKQ and STAT3. {ECO:0000250, ECO:0000269|PubMed:15632189, ECO:0000269|PubMed:17875724}.
結構域: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
亞細胞定位: Cytoplasm {ECO:0000269|PubMed:17603037}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17603037}. Cell membrane {ECO:0000269|PubMed:17603037}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). {ECO:0000250}.
翻譯後修飾: Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB. {ECO:0000269|PubMed:11964154, ECO:0000269|PubMed:19662078}.
相似的序列: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. {ECO:0000305}.; Contains 1 AGC-kinase C-terminal domain. {ECO:0000305}.; Contains 1 C2 domain. {ECO:0000255|PROSITE-ProRule:PRU00041}.; Contains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

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