PCSK9 cDNA ORF Clone in Cloning Vector, Human

Cat: HG15813-G

Contact us:

215-583-7898
order@sinobiological.com
Distributors

All PCSK9 Reagents

CRO Services

Product recommended


All PCSK9 Reagents

PCSK9 cDNA ORF Clone in Cloning Vector, Human General Information

Gene

Species
Human
NCBI Ref Seq
RefSeq ORF Size
2079 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 1420 G/A, 2009 G/A resulting in the amino acid Val substitution by Ile, Gly substitution by Glu and 1026 A/G,1380 A/G not causing the amino acid variation.
Description
Full length Clone DNA of Human proprotein convertase subtilisin/kexin type 9.

Plasmid

Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.

Screening

Antibiotic in E.coli
Ampicillin

Storage & Shipping

Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

PCSK9 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

PCSK9 cDNA ORF Clone in Cloning Vector, Human Alternative Names

FH3 cDNA ORF Clone, Human;HCHOLA3 cDNA ORF Clone, Human;LDLCQ1 cDNA ORF Clone, Human;NARC-1 cDNA ORF Clone, Human;NARC1 cDNA ORF Clone, Human;PC9 cDNA ORF Clone, Human

PCSK9 Background Information

Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

References

Full Name
proprotein convertase subtilisin/kexin type 9
References
  • Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.
  • Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498
  • Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.
  • Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
  • Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
  • PCSK9 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    PCSK9 cDNA ORF Clone in Cloning Vector, Rat RG80005-M
    PCSK9 cDNA ORF Clone, Rat, untagged RG80005-UT
    PCSK9 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80005-ACGLN
    PCSK9 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80005-ACG
    PCSK9 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80005-ACR
    PCSK9 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80005-CF
    PCSK9 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80005-NF
    PCSK9 cDNA ORF Clone, Rat, C-His tag RG80005-CH
    PCSK9 cDNA ORF Clone, Rat, N-His tag RG80005-NH
    PCSK9 cDNA ORF Clone, Rat, C-HA tag RG80005-CY
    PCSK9 cDNA ORF Clone, Rat, N-HA tag RG80005-NY
    PCSK9 cDNA ORF Clone, Rat, C-Myc tag RG80005-CM
    PCSK9 cDNA ORF Clone, Rat, N-Myc tag RG80005-NM
    PCSK9 qPCR Primer Pairs, Rat RP300005

    PCSK9 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    PCSK9 cDNA ORF Clone in Cloning Vector, Mouse MG50251-M
    PCSK9 cDNA ORF Clone, Mouse, untagged MG50251-UT
    PCSK9 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50251-ACG
    PCSK9 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50251-ACGLN
    PCSK9 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50251-ACR
    PCSK9 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50251-CF
    PCSK9 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50251-NF
    PCSK9 cDNA ORF Clone, Mouse, C-His tag MG50251-CH
    PCSK9 cDNA ORF Clone, Mouse, N-His tag MG50251-NH
    PCSK9 cDNA ORF Clone, Mouse, C-HA tag MG50251-CY
    PCSK9 cDNA ORF Clone, Mouse, N-HA tag MG50251-NY
    PCSK9 cDNA ORF Clone, Mouse, C-Myc tag MG50251-CM
    PCSK9 cDNA ORF Clone, Mouse, N-Myc tag MG50251-NM
    PCSK9 qPCR Primer Pairs, Mouse MP200277

    PCSK9 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    PCSK9 cDNA ORF Clone, Human, untagged HG15813-UT
    PCSK9 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG15813-ACGLN
    PCSK9 cDNA ORF Clone, Human, C-GFPSpark® tag HG15813-ACG
    PCSK9 cDNA ORF Clone, Human, C-OFPSpark® tag HG15813-ACR
    PCSK9 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG15813-CF
    PCSK9 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG15813-NF
    PCSK9 cDNA ORF Clone, Human, C-His tag HG15813-CH
    PCSK9 cDNA ORF Clone, Human, N-His tag HG15813-NH
    PCSK9 cDNA ORF Clone, Human, C-HA tag HG15813-CY
    PCSK9 cDNA ORF Clone, Human, N-HA tag HG15813-NY
    PCSK9 cDNA ORF Clone, Human, C-Myc tag HG15813-CM
    PCSK9 cDNA ORF Clone, Human, N-Myc tag HG15813-NM
    PCSK9 qPCR Primer Pairs, Human HP104404
    info info
    添加购物车成功! 添加购物车失败!