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P4HB 抗體, 兔單抗

  • P4HB Antibody, Rabbit MAb, Immunohistochemistry
  • P4HB Antibody, Rabbit MAb, Immunohistochemistry
  • P4HB Antibody, Rabbit MAb, Immunohistochemistry
產品資料評論相關產品實驗方法
小鼠 P4HB 抗體產品資訊
免疫原:Recombinant Mouse P4HB protein (Catalog#50638-M08H)
Clone ID:023
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS
抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse P4HB (rM P4HB; Catalog#50638-M08H; NP_035162.1; Met1-Lys506).
小鼠 P4HB Antibody IHC Application Image
P4HB Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of mouse P4HB in mouse brain with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
P4HB Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of mouse P4HB in mouse intestine with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
P4HB Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of mouse P4HB in mouse liver with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Other P4HB Antibody Products
P4HB 相关研究领域

P4HB 研究背景

Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein which belongs to the protein disulfide isomerase family. P4HB is highly abundant. In some cell types, it seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. P4HB localizes near CD4-enriched regions on lymphoid cell surfaces. It is identified by mass spectrometry in melanosome fractions from stage I to stage IV. P4HB reduces and may activate fusogenic properties of HIV-1 gp120 surface protein, thereby enabling HIV-1 entry into the cell. P4HB catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, it seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. P4HB may therefore cause structural modifications of exofacial proteins. Inside the cell, it seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, P4HB functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). P4HB may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

小鼠 P4HB 參考資料
  • Kivirikko KI, et al., 1989, FASEB J., 3 (5): 1609-17.
  • Pihlajaniemi T, et al.,1991, J Hepatol., 13, Suppl 3: S2
  • Fenouillet E., et al., 2001, J. Infect. Dis. 183:744-752.
  • Gevaert K., et al., 2003, Nat. Biotechnol. 21:566-569.
  • Barbouche R., et al., 2003, J. Biol. Chem. 278:3131-3136.
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    貨號: 50638-R023-100
    目錄價: 
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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