Anti-Olig2 Antibody

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Anti-Olig2 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-Olig2 Antibody
Validated applications
WB,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Olig2
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human Olig-2.
Preparation
This antibody was obtained from a rabbit immunized with purified, synthetic peptide corresponding to the N-terminus of the Human Olig-2.
Source
Monoclonal Rabbit IgG Clone #064
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Olig2 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
WB 1:500-1:2000
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Olig2 Antibody (Rabbit Monoclonal antibody) Images

Immunochemical staining of human olig-2 in human glioma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human olig-2 in human brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).

Anti-Olig-2 rabbit monoclonal antibody at 1:500 dilution

Lane A: Jurkat Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:32 kDa

Observed band size:37 kDa

Anti-Olig2 Antibody: Alternative Names

Anti-BHLHB1 Antibody; Anti-bHLHe19 Antibody; Anti-OLIGO2 Antibody; Anti-PRKCBP2 Antibody; Anti-RACK17 Antibody

Olig2 Background Information

Olig2, also known as Oligo2, is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. Oligo2 is structurally similar to OLIG1. Both of them have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Its over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in down syndrome. Olig2 may be a cause of a form of T-cell acute lymphoblastic leukemia.
Full Name
oligodendrocyte transcription factor 2
References
  • Wang J, et al., 2000, Proc Natl Acad Sci. 97(7): 3497-502.
  • Lu QR, et al., 2001, Proc Natl Acad Sci. 98(19): 10851-6.
  • Marie Y, et al., 2001, Lancet. 358(9278): 298-300.
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