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OCLN/Occludin  Protein, Antibody, ELISA Kit, cDNA Clone

OCLN/Occludin 相关研究领域

OCLN/Occludin 相關信號通路

    OCLN/Occludin 概述&蛋白信息

    OCLN/Occludin 研究背景

    亞單位結構: Interacts with TJP1/ZO1 and with VAPA. {ECO:0000269|PubMed:19017651}.
    結構域: The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity). The first extracellular loop participates in an adhesive interaction. {ECO:0000250, ECO:0000269|PubMed:9175707}.
    亞細胞定位: Membrane; Multi-pass membrane protein. Cell junction, tight junction.
    組織特異性: Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
    翻譯後修飾: Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1. Phosphorylation at Ser-490 also attenuates the interaction with TJP1. {ECO:0000269|PubMed:19017651, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:19125584, ECO:0000269|PubMed:19332538}.
    相關疾病 : DISEASE: Band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:251290]: A neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay. {ECO:0000269|PubMed:20727516}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the ELL/occludin family. {ECO:0000305}.; Contains 1 MARVEL domain. {ECO:0000255|PROSITE-ProRule:PRU00581}.
    General information above from UniProt

    OCLN/Occludin 別稱

    BLCPMG,PPP1R115, [homo-sapiens]
    Ocl,AI503564, [mus-musculus]

    OCLN/Occludin 相關文獻

    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”