All NRAS reagents are produced in house and quality controlled, including 2 NRAS Antibody, 26 NRAS Gene, 1 NRAS IPKit, 1 NRAS Protein, 2 NRAS qPCR. All NRAS reagents are ready to use.
Recombinant NRAS proteins are expressed by E. coli with fusion tags as N-His.
NRASantibodies are validated with different applications, which are WB, ELISA, IP.
NRAScDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each NRAS of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
NRAS was discovered by researchers at the Institute of Cancer Research, funded by the Cancer Research Campaign (now Cancer Research UK). NRAS gene is a member of the Ras gene family. It is mapped on chromosome 1, and it is activated in HL60, a promyelocytic leukemia line. The mammalian ras gene family consists of the harvey and kirsten ras genes (HRAS and KRAS), an inactive pseudogene of each (c-Hras2 and c-Kras1) and the N-ras gene. They differ significantly only in the C-terminal 40 amino acids. These ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. The NRAS gene specifies two main transcripts of 2Kb and 4.3Kb. The difference between the two transcripts is a simple extension through the termination site of the 2Kb transcript. The NRAS gene consists of seven exons (-I, I, II, III, IV, V, VI).