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NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a heterodimer composed of homo- and heterodimers of five members of the Rel family including NFKB1 (p50), NFkB2 (p52), RelA (p65), RelB, and c-Rel (Rel). There are a variety of inducers which can activate NF-κB, including LPS (Lipopolysaccharides) or inflammatory cytokines such as TNF (Tumour Necrosis Factor) or IL-1 (Interleukin-1), growth factors, lymphokines, oxidant-free radicals, inhaled particles, viral infection or expression of certain viral or bacterial gene products, UV irradiation, B or T-Cell activation, and by other physiological and non physiological stimuli.

Sino Biological offers a comprehensive set of tools for NF-kB Pathway (NFkB Pathway) related studies, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones.

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NF-kB(NFKB)通路 Related Products Index

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NF-kB(NFKB)通路 By Species

NF-kB(NFKB)通路 by Signaling Pathways

NF-kB(NFKB)通路 Background

NF-kB(NFKB)通路 References

  1. Gilmore TD. (2006) Introduction to NF-κB: players, pathways, perspectives. Oncogene. 25(51): 6680-4.
  2. Brasier AR. (2006) The NF-κB regulatory network. Cardiovasc Toxicol. 6(2):111-30.
  3. Perkins ND. (2007) Integrating cell-signalling pathways with NF-κB and IKK function. Nat Rev Mol Cell Biol. 8(1):49-62.
  4. Gilmore TD. (1999) The Rel/NF-κB signal transduction pathway: introduction. Oncogene. 18(49): 6842-4.
  5. Tian B, et al. (2003) Identification of a nuclear factor κ B-dependent gene network. Recent Prog Horm Res. 58:95-130.
  6. Albensi BC, et al. (2000) Evidence for the involvement of TNF and NF-κB in hippocampal synaptic plasticity. Synapse. 35(2):151-9.