NELL2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All NELL2 reagents are produced in house and quality controlled, including 3 NELL2 Antibody, 13 NELL2 Gene, 1 NELL2 Lysate, 1 NELL2 Protein, 1 NELL2 qPCR. All NELL2 reagents are ready to use.

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NELL2 Related Research Area

NELL2 Background

A brain-enriched secreting signal peptide, NELL2, has been suggested to play multiple roles in the development, survival, and activity of neurons in mammal. NELL2 is an abundant glycoprotein containing EGF-like domain in the neural tissues where it has multiple physiological functions by interacting with protein kinase C (PKC). There are two different splicing variant forms of NELL2 identified so far. One is secreted NELL2 (sNELL2) which is a neuron-specific variant and the other is cytosolic NELL2 (cNELL2) which is non-secreted splicing variant of NELL2. NELL2 is strongly expressed in brain of adult and fetus but only weakly in fetal kidney.

NELL2 References

  • Kuroda S, et al. (1999) Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. Biochem Biophys Res Commun. 265(1): 79-86.
  • Oyasu M, et al. (2000) Immunocytochemical localization of a neuron-specific thrombospondin-1-like protein, NELL2: light and electron microscopic studies in the rat brain. Brain Res Mol Brain Res. 76(1): 151-60.
  • Nelson BR, et al. (2002) Restricted neural epidermal growth factor-like like 2 (NELL2) expression during muscle and neuronal differentiation. Mech Dev. 119 Suppl 1: 11-9.