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小鼠 TNFR2 / CD120b / TNFRSF1B ELISA Kit

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檢測原理
Solid Phase Sandwich ELISA
預期用途
For the quantitative determination of Mouse TNFR2 / CD120b / TNFRSF1B concentration in serum.
The use of this kit for other sample types need be validated by the end user due to the complexity of natural targets and unpredictable interference.
線性範圍
6.25-400 pg/mL
靈敏度
The minimum detectable dose of Mouse TNFR2 / CD120b / TNFRSF1B is typically less than 5.8 pg/mL. The MDD was determined by adding three standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration.
試劑盒組分
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
儲存方法
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA
小鼠 TNFRSF1B ELISA Kit Standard Curve
Mouse TNFR2 / CD120b / TNFRSF1B ELISA Kit, TYPICAL DATA
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Caption:
This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
小鼠 TNFRSF1B ELISA Kit Specificity
Mouse TNFR2 / CD120b / TNFRSF1B ELISA Kit, SPECIFICITY
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Caption:
This assay recognizes both recombinant and natural mouse TNFRSF1B. The factors listed above were prepared at 50 ng/mL in dilution buffer and assayed for cross-reactivity and interference. No cross-reactivity or interference was observed.

TNFR2/TNFRSF1B/CD120b 研究背景

Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

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小鼠 TNFR2/TNFRSF1B/CD120b 參考資料
  • Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
  • Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
  • Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
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    貨號: KIT50128-1
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    產品圖片
    • Mouse TNFR2 / CD120b / TNFRSF1B ELISA Kit, TYPICAL DATA
    • Mouse TNFR2 / CD120b / TNFRSF1B ELISA Kit, SPECIFICITY
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