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小鼠 Smad3 基因全長cDNA ORF克隆 (表達載體)

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    小鼠 SMAD3 cDNA Clone產品資訊
    註冊碼:NM_016769.4
    cDNA基因長度:1278bp
    cDNA基因描述:Full length Clone DNA of Mus musculus MAD homolog 3 (Drosophila).
    基因別名:Madh3, AU022421, Smad3
    分子種屬:Mouse
    載體:pCMV3-untagged
    Plasmid:pCMV3-mSMAD3
    限制性酶切位點:KpnI + XbaI (6.1kb + 1.28kb)
    Tag序列:
    序列資訊:Identical with the Gene Bank Ref. ID sequence.
    Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
    ( We provide with Smad3 qPCR primers for gene expression analysis, MP200957 )
    Promoter:Enhanced CMV mammalian cell promoter
    Application:Stable or Transient mammalian expression
    Antibiotic in E.coli:Ampicillin
    Antibiotic in mammalian cell:Hygromycin
    運輸條件:Each tube contains lyophilized plasmid.
    儲存方法:The lyophilized plasmid can be stored at room temperature for three months.
    Product nameProduct name
    研究背景

    SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice, mutation of SMAD3 has been linked to colorectal adenocarcinoma, increased systemic inflammation, and accelerated wound healing. Increased SMAD3 activity has been implicated in the pathogenesis of scleroderma. Smad3 is also a multifaceted regulator in adipose physiology and the pathogenesis of obesity and type 2 diabetes.

    參考資料
  • Tan. et al., 2011, Diabetes. 60 (2): 464-76.
  • Yang X. et al., 1999, Nat Cell Biol. 1 (5): 260-6.
  • Zhu Y. et al., 1998, Cell. 94 (6): 703-14.
  • Feng X. et al., 1996, Nature. 383 (6596): 168-72.
  • Size / Price
    貨號: MG50991-UT
    目錄價: 
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    Datasheet & Documentation

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