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小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體)

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Mouse LTA4H cDNA Clone產品資訊
註冊碼:NM_008517.2
cDNA基因長度:1836bp
cDNA基因描述:Full length Clone DNA of Mus musculus leukotriene A4 hydrolase.
基因別名:Lta4h
分子種屬:Mouse
載體:pCMV3-untagged
Plasmid:
限制性酶切位點:
Tag序列:
序列資訊:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:Hygromycin
運輸條件:Each tube contains lyophilized plasmid.
儲存方法:The lyophilized plasmid can be stored at room temperature for three months.
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體) on other vectors
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤MG50268-ACGNT$8880
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤MG50268-ACRNT$8880
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), N-GFPSpark 標籤MG50268-ANGNT$8880
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), N-OFPSpark 標籤MG50268-ANRNT$8880
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤MG50268-CFNT$7790
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), C-His 標籤MG50268-CHNT$7790
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤MG50268-CMNT$7790
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤MG50268-CYNT$7790
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF(克隆載體)MG50268-MNT$2720
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤MG50268-NFNT$7790
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), N-His 標籤MG50268-NHNT$7790
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤MG50268-NMNT$7790
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤MG50268-NYNT$7790
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因全長cDNA ORF克隆 (表達載體)MG50268-UTNT$7790
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研究背景

Mouse leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

參考資料
  • Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71.
  • Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73.
  • Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82.
  • Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.
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    貨號: MG50268-UT
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    庫存2-3 weeks
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