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兔 Anti-Mouse IgM / Immunoglobulin M 抗體, 兔多抗

    產品資料評論相關產品實驗方法
    小鼠 IgM 抗體產品資訊
    免疫原:Recombinant Mouse IgM
    Clone ID:
    Ig類型:Rabbit IgG
    濃度:
    內毒素:
    緩衝液:0.2 μm filtered solution in PBS with 5% trehalose
    抗體製備方法:Produced in rabbits immunized with purified recombinant Mouse IgM protein. Total IgG was purified by Protein A affinity chromatography.
    Other IgM Antibody Products
    Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
    IgM 研究背景

    Antibodies, also known as Immunoglobulins ( Ig ), are gamma globulin proteins that are found in blood or other bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses. Antibodies can come in different varieties known as isotypes or classes. In placental mammals there are five antibody isotypes known as IgA, IgD, IgE, IgG and IgM. They are each named with an "" Ig "" prefix that stands for immunoglobulin, another name for antibody, and differ in their biological properties, functional locations and ability to deal with different antigens. IgM is expressed on the surface of B cells and in a secreted form with very high avidity. It eliminates pathogens in the early stages of B cell mediated immunity before there is sufficient IgG. IgM is by far the physically largest antibody in the human circulatory system. It is produced after an animal has been exposed to an antigen for an extended time or when an animal is exposed to an antigen for the second time. IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, mostly as a pentamer but also as a hexamer. Because each monomer has two antigen binding sites, a pentameric IgM has 10 binding sites. Typically, however, IgM cannot bind 10 antigens at the same time because the large size of most antigens hinders binding to nearby sites. Due to its polymeric nature, IgM possesses high avidity, and is particularly effective at complement activation.

    小鼠 IgM 參考資料
  • Litman, GW. et al., 1993, Mol. Biol. Evol. 10 (1): 60-72.
  • Eleonora, MF. et al., 2003, PLoS Biology. 1 (1): e16.
  • Woof, J. et al., 2004, Nat Rev Immunol. 4 (2): 89-99.
  • Pier, GB. et al., 2004, ASM Press. ISBN 1-55581-246-5.
  • Geisberger, R. et al., 2006, Immunology. 118 (4): 429-37.
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”