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小鼠 CD132 / IL2RG ELISA Kit

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檢測原理
Solid Phase Sandwich ELISA
預期用途
For the quantitative determination of Mouse CD132 / IL2RG concentration in serum.
The use of this kit for other sample types need be validated by the end user due to the complexity of natural targets and unpredictable interference.
線性範圍
31.25-2000 pg/mL
靈敏度
The minimum detectable dose of Mouse CD132 / IL2RG is typically less than 15.53 pg/mL. The MDD was determined by adding three standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration.
試劑盒組分
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
儲存方法
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA
小鼠 IL2RG ELISA Kit Standard Curve
Mouse CD132 / IL2RG ELISA Kit, TYPICAL DATA
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Caption:
This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
小鼠 IL2RG ELISA Kit Specificity
Mouse CD132 / IL2RG ELISA Kit, SPECIFICITY
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Caption:
This assay recognizes both recombinant and natural Mouse IL2RG. The factors listed below were prepared at 50 ng/mL in dilution buffer and assayed for cross-reactivity. No cross-reactivity was observed.
CD132 / IL2RG 研究背景

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

小鼠 CD132 / IL2RG 參考資料
  • Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
  • Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
  • Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.
  • Size / Price
    貨號: KIT50087-1
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    產品圖片
    • Mouse CD132 / IL2RG ELISA Kit, TYPICAL DATA
    • Mouse CD132 / IL2RG ELISA Kit, SPECIFICITY
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