MCP-5 Protein, Mouse, Recombinant (His Tag)

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MCP-5 Protein, Mouse, Recombinant (His Tag): Product Information

Purity
> (58.5+36.0) % as determined by SDS-PAGE.
Endotoxin
Please contact us for more information.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mouse Ccl12 (NP_035461.2) (Gly23-Gly104) was expressed with a polyhistidine tag at the C-terminus.
Accession#
Expressed Host
Yeast
Species
Mouse
Predicted N Terminal
Gly 23
Molecule Mass
The recombinant mouse Ccl12 consists of 92 amino acids and predicts a molecular mass of 10.7 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

MCP-5 Protein, Mouse, Recombinant (His Tag): Images

MCP-5 Protein, Mouse, Recombinant (His Tag): Alternative Names

CCL12 Protein, Mouse; MCP-5 Protein, Mouse; Scya12 Protein, Mouse

MCP-5 Background Information

Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impaired fibronectin and collagen deposition and indirectly stimulated collagen degradation through upregulation of matrix metalloproteinase-2. In post-MI patients, circulating LPS levels strongly associated with the Ccl12 homologue monocyte chemotactic protein 1 (MCP-1). Both MCP-1 and MCP-5 are HIF-1 target genes and that HIF-1alpha is involved in transcriptional induction of these two chemokines in astrocytes by hypoxia.
Full Name
chemokine (C-C motif) ligand 12
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