|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤||MG50501-ACG|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤||MG50501-ACR|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤||MG50501-CF|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), C-His 標籤||MG50501-CH|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤||MG50501-CM|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤||MG50501-CY|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF(克隆載體)||MG50501-M|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤||MG50501-NF|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), N-His 標籤||MG50501-NH|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤||MG50501-NM|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤||MG50501-NY|
|小鼠 CADM4/IGSF4C/NECL-4 基因全長cDNA ORF克隆 (表達載體)||MG50501-UT|
Immunoglobulin superfamily member 4C (IGSF4C), also known as CADM4 or NECL-4, is an immunoglobulin (Ig) superfamily molecule showing significant homology with a lung tumor suppressor, TSLC1. CADM4/IGSF4C/NECL-4 protein is mainly expressed in the kidney, bladder, and prostate in addition to the brain. Experiments have reported the biological significance of CADM4/IGSF4C/NECL-4 in the urinary tissues. An immunohistochemical study reveals that CADM4 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate. IGSF4-immunoreactivity (IR) was observed diffusely in the telencephalic wall, whereas it became rather confined to the subplate, the cortical plate and the subventricular zone as the development proceeded. IGSF4-IR gradually decreased after birth and disappeared in adulthood. IGSF4 remained at low levels throughout embryonic stage, whereas it increased after birth. These spatiotemporal patterns of the expression suggest that IGSF4 plays crucial roles in the development of both telencephalon and cerebellum. CADM4/IGSF4C/NECL-4 is ectopically expressed in adult T-cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion. The distinct roles of CADM4/IGSF4C/NECL-4 in the oncogenesis of carcinomas and ATL could be due to tissue-specific differences in the downstream cascades, and is a novel concept with respect to cell adhesion in human oncogenesis.