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小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), N-His 標籤

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Mouse ALOX5AP cDNA Clone產品資訊
註冊碼:NM_009663.1
cDNA基因長度:486bp
cDNA基因描述:Full length Clone DNA of Mus musculus arachidonate 5-lipoxygenase activating protein with N terminal His tag.
基因別名:Flap
分子種屬:Mouse
載體:pCMV3-N-His
Plasmid:
限制性酶切位點:
Tag序列:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
序列資訊:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
運輸條件:Each tube contains lyophilized plasmid.
儲存方法:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.

小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), N-His 標籤 on other vectors
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤MG52815-ACGNT$8150
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤MG52815-ACRNT$8150
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), N-GFPSpark 標籤MG52815-ANGNT$8150
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), N-OFPSpark 標籤MG52815-ANRNT$8150
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤MG52815-CFNT$7060
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), C-His 標籤MG52815-CHNT$7060
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤MG52815-CMNT$7060
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤MG52815-CYNT$7060
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF(克隆載體)MG52815-GNT$2720
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤MG52815-NFNT$7060
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), N-His 標籤MG52815-NHNT$7060
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤MG52815-NMNT$7060
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤MG52815-NYNT$7060
小鼠 ALOX5AP / 5-lipoxygenase-activating 蛋白 基因全長cDNA ORF克隆 (表達載體)MG52815-UTNT$7060
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研究背景

Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk for myocardial infarction, stroke and restenosis, reigniting pharmaceutical interest in this target. It had been found that ALOX5AP/FLAP is a key enzyme in leukotriene formation, in both human pulmonary microvascular endothelial cells and a transformed human brain endothelial cell line. In addition, the protein FLAP has recently been identified as an emerging target in metabolic disease. In fact, FLAP is overexpressed in the adipose tissue of patients and experimental animals with obesity.

參考資料
  • Gonsalves CS, et al. (2010) Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p. J Immunol. 184(7): 3878-88.
  • Zintzaras E, et al. (2009) Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. Am J Epidemiol. 169(5): 523-32.
  • Evans JF, et al. (2008) What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. Trends Pharmacol Sci. 29(2): 72-8.
  • Bck M, et al. (2007) 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Circ Res. 100: 946-9.
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    貨號: MG52815-NH
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