MUSK (Protein|Antibody|cDNA Clone|ELISA Kit)

All MUSK reagents are produced in house and quality controlled, including 2 MUSK Antibody, 4 MUSK Gene, 1 MUSK IPKit, 1 MUSK Lysate, 1 MUSK Protein, 1 MUSK qPCR. All MUSK reagents are ready to use.

Recombinant MUSK proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-GST & His.

MUSKantibodies are validated with different applications, which are IP, WB.

MUSKcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each MUSK of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

MUSK Protein (1)

Species

MUSK Protein, Human, Recombinant (aa 433-783, His & GST Tag)

11918-H20B

Expression host: Baculovirus-Insect Cells

Human MUSK Protein 9883
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MUSK Antibody (2)

Application
Clonality
Host

Anti-MUSK Antibody

100975-T02

Application: IP

Clonality: PAb

Human MUSK Immunoprecipitation(IP) 14595

Anti-MUSK Antibody

100975-T36

Application: WB,IP

Clonality: PAb

Human MUSK Immunoprecipitation(IP) 14595
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MUSK cDNA Clone (4)

Human
NM_001166280.1
NM_005592.3

MUSK qPCR Primer (1)

MUSK IP Kit (1)

MUSK Lysate (1)

Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and tyr protein kinase family. MUSK contains one FZ (frizzled) domain, three Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. This protein is a muscle-specific tyrosine kinase receptor and it may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. MUSK expression is increased in muscle cells stimulated with Wnt or at conditions when the Wnt signaling was activated. MUSK is a muscle-specific receptor tyrosine kinase that is activated by agrin. It has a critical role in neuromuscular synapse formation. MUSK is a receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization. Defects in MUSK encoding gene is a cause of autosomal recessive congenital myasthenic syndrome (CMS). Congenital myasthenic syndromes are inherited disorders of neuromuscular transmission that stem from mutations in presynaptic, synaptic, or postsynaptic proteins. MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction. Mutations in this receptor encoding gene also have been associated with congenital myasthenic syndrome.

Protein
Antibody
Gene
qPCR
IPKit
Lysate
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