MOG / Myelin Oligodendrocyte Glycoprotein (Protein | Antibody | cDNA Clone | ELISA Kit)

All MOG / Myelin Oligodendrocyte Glycoprotein reagents are produced in house and quality controlled, including 7 MOG / Myelin Oligodendrocyte Glycoprotein Antibody, 27 MOG / Myelin Oligodendrocyte Glycoprotein Gene, 2 MOG / Myelin Oligodendrocyte Glycoprotein Protein, 2 MOG / Myelin Oligodendrocyte Glycoprotein qPCR. All MOG / Myelin Oligodendrocyte Glycoprotein reagents are ready to use.

MOG / Myelin Oligodendrocyte Glycoprotein Protein (2)

MOG / Myelin Oligodendrocyte Glycoprotein Antibody (7)

MOG / Myelin Oligodendrocyte Glycoprotein cDNA Clone (27)

NM_206809.2
NM_206814.5

In expression vector

NM_010814.2

MOG / Myelin Oligodendrocyte Glycoprotein Related Research Area

MOG / Myelin Oligodendrocyte Glycoprotein Background

Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately .1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.

MOG / Myelin Oligodendrocyte Glycoprotein References

  • Chekhonin VP, et al. (2003) Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders. Biomed Khim. 49(5): 411-23.
  • Hilton AA, et al. (1995) Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein. J Neurochem. 65(1): 309-18.
  • Johns TG, et al. (1999) The Structure and Function of Myelin Oligodendrocyte Glycoprotein. J Neurochem. 72(1): 1-9.