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MMP-8 / MMP8  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
10254-HNAH-20
10254-HNAH-10
20 µg 
10 µg 
Add to Cart
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描述: Active  
表達宿主: Human Cells  
10254-H08H-20
10254-H08H-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
50493-MNAH-20
50493-MNAH-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
表達宿主: CHO Stable Cells  
50493-M08S-20
50493-M08S-10
20 µg 
10 µg 
Add to Cart
  • Slide 1

MMP-8 / MMP8 相关研究领域

MMP-8 / MMP8 相關信號通路

    MMP-8 / MMP8 概述&蛋白信息

    MMP-8 / MMP8 研究背景

    基因概述: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by MMP8 gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. MMP8 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
    輔因數: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 3 Ca(2+) ions per subunit.;; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
    酶調控: ENZYME REGULATION: Cannot be activated without removal of the activation peptide.
    亞單位結構: Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1 (By similarity).
    結構域: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    亞細胞定位: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Note=Stored in intracellular granules.
    組織特異性: Neutrophils.
    相似的序列: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. Neutrophil collagenase, also known as Matrix metalloproteinase-8, MMP-8, and CLG1, is a member of the peptidase M10A family. MMP-8 may affect the metastatic behaviour of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumour may have a protective effect against lymph node metastasis. MMP-8 may affect the metastatic behaviour of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 participates in wound repair by contributing to the resolution of inflammation and open the possibility to develop new strategies for treating wound healing defects.

    MMP-8 / MMP8 別稱

    MMP-8 / MMP8 相關文獻

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