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MMP-16  Protein, Antibody, ELISA Kit, cDNA Clone

MMP-16 相关研究领域

MMP-16 相關信號通路

    MMP-16 概述&蛋白信息

    MMP-16 研究背景

    輔因數: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000250};; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
    酶調控: ENZYME REGULATION: TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.
    亞單位結構: Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. {ECO:0000269|PubMed:11278606, ECO:0000269|PubMed:14741217}.
    結構域: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    亞細胞定位: Isoform Long: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells.; Isoform Short: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.
    組織特異性: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
    發育階段: Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
    翻譯後修飾: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
    相似的序列: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    MMP-16 別稱

    MMP-16 相關文獻

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