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MMP-14/MMP14  Protein, Antibody, ELISA Kit, cDNA Clone

MMP-14/MMP14 相关研究领域

MMP-14/MMP14 相關信號通路

    MMP-14/MMP14 概述&蛋白信息

    MMP-14/MMP14 研究背景

    催化活性: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
    輔因數: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000250};; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
    亞單位結構: Interacts (via C-terminal cytoplasmic tail) with BST2. {ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:9724659}.
    結構域: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    亞細胞定位: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
    組織特異性: Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269|PubMed:18223680}.
    誘導: Up-regulated by NANOS1. {ECO:0000269|PubMed:18223680}.
    翻譯後修飾: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.; Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
    相關疾病 : DISEASE: Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. {ECO:0000269|PubMed:22922033}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    MMP-14/MMP14 別稱

    MMP-14/MMP14 相關文獻

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