All MART-1 reagents are produced in house and quality controlled, including 1 MART-1 Antibody, 15 MART-1 Gene, 1 MART-1 qPCR. All MART-1 reagents are ready to use.
MART-1antibodies are validated with different applications, which are IHC-P.
MART-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each MART-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
MART-1 is a hydrophobic transmembrane protein without glycosylation sites highly enriched in early melanosomes. MART-1 is necessary for gp100 function, another antigen associated to cutaneous melanom, involved in the regulation of melanosome formation. MART-1 is expressed in skin and retinae melanocytes and in the majority of melanoma tumors, but it is absent from other tissues and tumors. It was isolated thanks to the specific recognition by T lymphocytes of MART-1 derived peptides, specially in the context of the HLA-A0201 haplotype, present in tumor infiltrates from melanoma patients. Thus, MART-1 is immunogenic in humans and has been widely exploited to induce anti-melanoma immunity in patients by means of several vaccination strategies.