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MLANA  Protein, Antibody, ELISA Kit, cDNA Clone

MLANA 相关研究领域

MLANA 相關信號通路

    MLANA 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    MLANA 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    Featured Reagent Products

    MLANA 概述&蛋白信息

    MLANA 研究背景

    亞單位結構: Interacts with PMEL. Interacts with GPR143. {ECO:0000269|PubMed:15695812, ECO:0000269|PubMed:19717472, ECO:0000269|PubMed:20417641}.
    亞細胞定位: Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
    組織特異性: Expression is restricted to melanoma and melanocyte cell lines and retina.
    翻譯後修飾: Acylated. {ECO:0000269|PubMed:12191019}.

    MART-1 is a hydrophobic transmembrane protein without glycosylation sites highly enriched in early melanosomes. MART-1 is necessary for gp100 function, another antigen associated to cutaneous melanom, involved in the regulation of melanosome formation. MART-1 is expressed in skin and retinae melanocytes and in the majority of melanoma tumors, but it is absent from other tissues and tumors. It was isolated thanks to the specific recognition by T lymphocytes of MART-1 derived peptides, specially in the context of the HLA-A0201 haplotype, present in tumor infiltrates from melanoma patients. Thus, MART-1 is immunogenic in humans and has been widely exploited to induce anti-melanoma immunity in patients by means of several vaccination strategies.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    MLANA 別稱

    MART1,MART-1, [homo-sapiens]
    Mart1,A930034P04Rik, [mus-musculus]

    MLANA 相關文獻

  • Barrio MM, Abes R, Colombo M, et al. Human Macrophages and Dendritic Cells Can Equally Present MART-1 Antigen to CD8+ T Cells after Phagocytosis of Gamma-Irradiated Melanoma Cells. Chatenoud L, ed. PLoS ONE. 2012;7(7):e40311.
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