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MIF  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
10246-H08H-20
10246-H08H-10
20 µg 
10 µg 
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  • Slide 1
表達宿主: Human Cells  
50066-M08H-50
50066-M08H-20
50 µg 
20 µg 
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  • Slide 1
表達宿主: E. coli  
50066-MNAE-50
50066-MNAE-20
50 µg 
20 µg 
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MIF 相关研究领域

MIF 相關信號通路

    MIF 概述&蛋白信息

    MIF 研究背景

    基因概述: MIF gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: Keto-phenylpyruvate = enol-phenylpyruvate.; L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
    亞單位結構: Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL. {ECO:0000250, ECO:0000269|PubMed:11089976, ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:12681488, ECO:0000269|PubMed:12782713, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677, ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:23776208}.
    亞細胞定位: Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
    誘導: Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens. {ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:2552447}.
    相關疾病 : DISEASE: Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    相似的序列: Belongs to the MIF family. {ECO:0000305}.
    General information above from UniProt

    Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine, the effect of which on arresting random immune cell movement was recognized several decades ago. Despite its historic name, MIF also has a direct chemokine-like function and promotes cell recruitment. MIF is an ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. Further research has shown that MIF plays a particularly critical part in cell cycle regulation and therefore in tumorigenesis as well. The significance of the role of MIF in a variety of both solid and hematologic tumors has been established. More recently, interest has increased in the role of MIF in the development of central nervous system (CNS) tumors, in which it appears to influence cell cycle control. MIF contributes to malignant disease progression on several different levels. Both circulating and intracellular MIF protein levels are elevated in cancer patients and MIF expression reportedly correlates with stage, metastatic spread and disease-free survival. Blockade of MIF bioactivity successfully inhibited tumor cell growth in vivo and in vitro. MIF plays important roles in the pathogenesis of gastrointestinal, hepatic, and pancreatic disorders.

    MIF 別稱

    GIF,GLIF,MMIF, [homo-sapiens]
    MIF,GIF,GLIF,MMIF, [human]
    DER6,GIF,Glif,MGC107654,Mif, [mouse]
    GIF,Glif, [mus-musculus]

    MIF 相關文獻

  • Ohkawara T, et al. (2005) Pathophysiological roles of macrophage migration inhibitory factor in gastrointestinal, hepatic, and pancreatic disorders. J Gastroenterol. 40(2): 117-22.
  • Bach JP, et al.. (2009) The role of macrophage inhibitory factor in tumorigenesis and central nervous system tumors. Cancer. 115(10): 2031-40.
  • Rendon BE, et al.. (2009) Mechanisms of macrophage migration inhibitory factor (MIF)-dependent tumor microenvironmental adaptation. Exp Mol Pathol. 86(3): 180-5.
  • Grieb G, et al. (2010) Macrophage migration inhibitory factor (MIF): a promising biomarker. Drug News Perspect. 23(4): 257-64.
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