MEK1 (Protein|Antibody|cDNA Clone|ELISA Kit)

All MEK1 reagents are produced in house and quality controlled, including 3 MEK1 Antibody, 32 MEK1 Gene, 2 MEK1 IPKit, 2 MEK1 Lysate, 2 MEK1 Protein, 2 MEK1 qPCR. All MEK1 reagents are ready to use.

Recombinant MEK1 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-GST & His, N-cleavage.

MEK1antibodies are validated with different applications, which are ELISA, WB, IHC-P, ICC/IF, IF, IP.

MEK1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each MEK1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

MEK1 Protein (2)

Species

MEK1 Protein, Mouse, Recombinant (His & GST Tag)

50312-M20B

Expression host: Baculovirus-Insect Cells

Mouse MEK1/MAP2K1/MKK1 Protein 11558

MEK1 Protein, Mouse, Recombinant

50312-MNCB

Expression host: Baculovirus-Insect Cells

Mouse MEK1/MAP2K1/MKK1 Protein 11559
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MEK1 Antibody (3)

Application Clonality
Host

Anti-MEK1 Antibody

50312-RP01

Application: ELISA

Clonality: PAb

Anti-MEK1 Antibody

101351-T38

Application: WB,ICC/IF,IF,IP

Clonality: PAb

Human MEK1/MAP2K1/MKK1 Western blot (WB) 17268

Anti-MEK1 Antibody

50312-T62

Application: WB,ELISA,IHC-P,ICC/IF,IF,IP

Clonality: PAb

Mouse MEK1/MAP2K1/MKK1 Western blot (WB) 15750
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MEK1 cDNA Clone (32)

Human
Rat
Mouse

MEK1 qPCR Primer (2)

MEK1 IP Kit (2)

MEK1 Lysate (2)

MEK1, also known as MAP2K1 and MKK1, is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MEK1 is widely expressed, with extremely low levels in brain. It lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Binding extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1 and MEK2. MEK1 has been shown to export PPARG from the nucleus. The MAPK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. MKK1 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Defects in MEK1 can cause cardiofaciocutaneous syndrome.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Protein
Antibody
Gene
qPCR
IPKit
Lysate
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