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LFA-3 / CD58  蛋白

All LFA-3 Reagents

表達宿主: Human Cells  
  • Slide 1
12409-H02H-50
12409-H02H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
12409-H08H-50
12409-H08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
90190-C08H-50
90190-C08H-100
50 µg 
100 µg 
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LFA-3 / CD58 相關信號通路

    LFA-3 / CD58 概述&蛋白信息

    LFA-3 / CD58 研究背景

    基因概述: This gene encodes a member of the immunoglobulin superfamily. LFA-3 is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. LFA-3 is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
    General information above from NCBI
    亞單位結構: Interacts with CD2.
    亞細胞定位: Isoform 1: Cell membrane; Single-pass type I membrane protein.
    Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.
    相似的序列: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.C
    General information above from UniProt

    CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

    LFA-3 / CD58 別稱

    LFA3, [Cynomolgus]
    ag3,CD58,CD58 antigen,CD58 molecule,LFA3,LFA-3,lymphocyte function-associated antigen 3,RP5-1086K13.2,surface glycoprotein LFA-3, [human]

    LFA-3 / CD58 相關文獻

  • Rochelle JM. et al., 1993, Int Immunol. 5 (2): 209-16.
  • Virtaneva KI. et al., 1993, Immunogenetics. 37 (6): 461-5.
  • Horejsí V. et al., 1991, FEBS Lett. 288 (1-2): 1-4.
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