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KLH / Keyhole Limpet Hemocyanin 抗體, 鼠單抗

    產品資料評論相關產品實驗方法
     KLH 抗體產品資訊
    免疫原:Recombinant KLH protein
    Clone ID:15F7E4G3
    Ig類型:Mouse IgG1
    濃度:
    內毒素:
    緩衝液:0.2 μm filtered solution in PBS with 5% trehalose
    抗體製備方法:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant KLH (Keyhole Limpet Hemocyanin). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other KLH Antibody Products
    KLH 研究背景

    KLH (Keyhole Limpet Hemocyanin) is a copper containing oxygen carrier occurring freely dissolved in the hemolymph of many molluscs and arthropods. KLH is used extensively as a carrier protein in the production of antibodies for research, biotechnology and therapeutic applications. Haptens are substances with a low molecular weight such as peptides, small proteins and drug molecules that are generally not immunogenic and require the aid of a carrier protein to stimulate a response from the immune system in the form of antibody production. KLH is the most widely employed carrier proteins for this purpose. It is an effective carrier protein for several reasons. Its large size and numerous epitopes generate a substantial immune response, and abundance of lysine residues for coupling haptens, allows a high hapten:carrier protein ratio increasing the likelihood of generating hapten-specific antibodies. KLH may also be a challenging molecule to work with because of its propensity to aggregate and precipitate. Aggregates remain immunogenic, but limit the ability to conjugate haptens and are difficult to manipulate in the laboratory. A high quality KLH preparation with the clear opalescent blue color is the best indicator of KLH solubility. KLH is being tested as a therapeutic vaccine for a variety of cancers, including non-Hodgkins lymphoma, cutaneous melanoma, breast and bladder cancer. These vaccines use specific tumor-associated antigens (Haptens) conjugated to KLH to stimulate the body’s immune system to generate anti-tumor immune responses which can destroy tumor cells.

     KLH 參考資料
  • Lamm, D.L. et al., 1993, Urol Res. 21 (1): 33-7.
  • Lamm, D.L. et al., 1993, J Urol. 149 (3): 648-52.
  • Jennemann, R. et al.,1994, J Biochem. 115 (6): 1047-52.
  • Harris, J.R. et al., 1999, Micron. 30 (6): 597-623.
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    貨號: 12133-MM04-200
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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