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Junctional Adhesion Molecule A  抗體

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反應性: Human  
應用 : ELISA  
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    反應性: Human  
    應用 : FCM  
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    反應性: Human  
    應用 : ELISA  
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      反應性: Human  
      應用 : ELISA  WB  IP  
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      反應性: Human  
      應用 : FCM  
      10198-MM04-A-25
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      反應性: Human  
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      10198-MM08-50
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        反應性: Human  
        應用 : FCM  IF  ICC/IF  
        10198-MM04-50
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        反應性: Human  
        應用 : FCM  
        10198-MM04-P-25
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        Junctional Adhesion Molecule A 相关研究领域

        Junctional Adhesion Molecule A 相關信號通路

          Junctional Adhesion Molecule A 相關蛋白、抗體、cDNA基因、ELISA試劑盒

          Junctional Adhesion Molecule A 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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          Junctional Adhesion Molecule A 概述&蛋白信息

          Junctional Adhesion Molecule A 研究背景

          基因概述: OMIM - description for Junctional Adhesion Molecule A :
          General information above from NCBI
          亞單位結構: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity). {ECO:0000250}.
          亞細胞定位: Cell junction, tight junction {ECO:0000269|PubMed:11171323}. Cell membrane {ECO:0000269|PubMed:11171323}; Single-pass type I membrane protein {ECO:0000269|PubMed:11171323}. Note=Localized at tight junctions of both epithelial and endothelial cells.
          翻譯後修飾: N-glycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7646439}.
          相似的序列: Belongs to the immunoglobulin superfamily. {ECO:0000305}.; Contains 2 Ig-like V-type (immunoglobulin-like) domains. {ECO:0000305}.
          General information above from UniProt

          Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.

          Junctional Adhesion Molecule A 別稱

          Junctional Adhesion Molecule A 相關文獻

        • Guglielmi KM, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem. 282(24): 17930-40.
        • Yeung D, et al. (2008) Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol. 115(6): 635-42.
        • Ong KL, et al. (2009) Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 22(5): 500-5.
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